ctcRbase

Entry Detail

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General Information

Database ID: SKCM03328 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ATRX Full Name: ATRX, chromatin remodeler Category: mRNA Synonyms: JMS|MRX52|RAD54|RAD54L|XH2|XNP|ZNF-HX Chromosome: chrX Strand: - Coordinate: Start Site(bp): 77504878 End Site(bp): 77786269 Gene Summary: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017] External Links: Ensembl ID: ENSG00000085224 HGNC ID: HGNC:886 Entrez Gene: 546

Expression Profile of ATRX Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-139-5p YES YES YES hsa-miR-143-3p YES YES NO hsa-miR-144-3p YES NO YES hsa-miR-145-5p YES YES YES hsa-miR-154-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-27a-3p YES NO YES hsa-miR-27b-3p YES NO YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-384 YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-429 YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-494-3p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: