ctcRbase

Entry Detail

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General Information

Database ID: SKCM03336 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DROSHA Full Name: drosha ribonuclease III Category: mRNA Synonyms: ETOHI2|HSA242976|RANSE3L|RN3|RNASE3L|RNASEN Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 31400497 End Site(bp): 31532196 Gene Summary: This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016] External Links: Ensembl ID: ENSG00000113360 HGNC ID: HGNC:17904 Entrez Gene: 29102

Expression Profile of DROSHA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES NO YES hsa-miR-1298-5p YES NO YES hsa-miR-132-3p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-429 YES YES NO Display: