ctcRbase

Entry Detail

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General Information

Database ID: SKCM03337 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: AKAP13 Full Name: A-kinase anchoring protein 13 Category: mRNA Synonyms: AKAP-13|AKAP-Lbc|ARHGEF13|BRX|HA-3|Ht31|LBC|PRKA13|PROTO-LB|PROTO-LBC|c-lbc|p47 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 85380571 End Site(bp): 85749358 Gene Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012] External Links: Ensembl ID: ENSG00000170776 HGNC ID: HGNC:371 Entrez Gene: 11214

Expression Profile of AKAP13 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO NO hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-107 YES NO NO hsa-miR-124-3p YES NO NO hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-126-3p YES NO YES hsa-miR-134-5p NO YES YES hsa-miR-136-5p YES YES NO hsa-miR-143-3p YES NO YES hsa-miR-17-5p YES YES YES hsa-miR-199a-5p YES NO YES hsa-miR-199b-5p YES NO YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-219a-5p YES YES YES hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-488-3p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES NO NO hsa-miR-519d-3p YES YES YES hsa-miR-582-5p YES NO YES hsa-miR-93-5p YES YES YES Display: