ctcRbase

Entry Detail

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General Information

Database ID: SKCM03355 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TRIB2 Full Name: tribbles pseudokinase 2 Category: mRNA Synonyms: C5FW|GS3955|TRB2 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 12716889 End Site(bp): 12742734 Gene Summary: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] External Links: Ensembl ID: ENSG00000071575 HGNC ID: HGNC:30809 Entrez Gene: 28951

Expression Profile of TRIB2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-100-5p YES YES YES hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-1297 YES YES YES hsa-miR-132-3p YES NO YES hsa-miR-139-5p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES YES YES hsa-miR-18b-5p YES YES YES hsa-miR-193a-3p YES YES YES hsa-miR-193b-3p YES YES YES hsa-miR-212-3p YES NO YES hsa-miR-22-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-299-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-370-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-487a-3p YES NO YES hsa-miR-542-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-874-3p YES YES NO hsa-miR-98-5p YES NO YES hsa-miR-99a-5p YES YES YES hsa-miR-99b-5p YES YES YES Display: