ctcRbase

Entry Detail

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General Information

Database ID: SKCM03360 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RBBP8 Full Name: RB binding protein 8, endonuclease Category: mRNA Synonyms: COM1|CTIP|JWDS|RIM|SAE2|SCKL2 Chromosome: chr18 Strand: + Coordinate: Start Site(bp): 22798261 End Site(bp): 23026488 Gene Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000101773 HGNC ID: HGNC:9891 Entrez Gene: 5932

Expression Profile of RBBP8 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-18a-5p YES YES YES hsa-miR-18b-5p YES YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-205-5p YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-340-5p YES NO YES hsa-miR-454-3p YES YES YES hsa-miR-488-3p YES YES NO Display: