ctcRbase

Entry Detail

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General Information

Database ID: SKCM03377 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MAP3K12 Full Name: mitogen-activated protein kinase kinase kinase 12 Category: mRNA Synonyms: DLK|MEKK12|MUK|ZPK|ZPKP1 Chromosome: chr12 Strand: - Coordinate: Start Site(bp): 53479669 End Site(bp): 53500063 Gene Summary: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010] External Links: Ensembl ID: ENSG00000139625 HGNC ID: HGNC:6851 Entrez Gene: 7786

Expression Profile of MAP3K12 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-140-5p YES YES NO hsa-miR-150-5p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-191-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-299-3p YES YES YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-519d-3p YES YES YES hsa-miR-93-5p YES YES YES Display: