ctcRbase

Entry Detail

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General Information

Database ID: SKCM03392 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ITGAV Full Name: integrin subunit alpha V Category: mRNA Synonyms: CD51|MSK8|VNRA|VTNR Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 186590065 End Site(bp): 186680901 Gene Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015] External Links: Ensembl ID: ENSG00000138448 HGNC ID: HGNC:6150 Entrez Gene: 3685

Expression Profile of ITGAV Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-136-5p YES YES NO hsa-miR-137 YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-142-3p YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-144-3p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-192-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-215-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-299-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-496 YES YES NO hsa-miR-875-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: