ctcRbase

Entry Detail

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General Information

Database ID: SKCM03395 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PFKFB4 Full Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Category: mRNA Synonyms: - Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 48517684 End Site(bp): 48562015 Gene Summary: The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] External Links: Ensembl ID: ENSG00000114268 HGNC ID: HGNC:8875 Entrez Gene: 5210

Expression Profile of PFKFB4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-25-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-324-5p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: