ctcRbase

Entry Detail

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General Information

Database ID: SKCM03396 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SKAP2 Full Name: src kinase associated phosphoprotein 2 Category: mRNA Synonyms: PRAP|RA70|SAPS|SCAP2|SKAP-HOM|SKAP55R Chromosome: chr7 Strand: - Coordinate: Start Site(bp): 26667062 End Site(bp): 26995239 Gene Summary: The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] External Links: Ensembl ID: ENSG00000005020 HGNC ID: HGNC:15687 Entrez Gene: 8935

Expression Profile of SKAP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-132-3p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-193a-3p YES YES YES hsa-miR-193b-3p YES YES YES hsa-miR-205-5p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-28-5p YES YES NO hsa-miR-320a YES NO YES hsa-miR-320b YES NO YES hsa-miR-320c YES NO YES hsa-miR-320d YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-411-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-496 YES YES NO hsa-miR-668-3p YES NO YES hsa-miR-708-5p YES YES NO hsa-miR-9-5p YES YES NO Display: