ctcRbase

Entry Detail

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General Information

Database ID: SKCM03445 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PTPN11 Full Name: protein tyrosine phosphatase, non-receptor type 11 Category: mRNA Synonyms: BPTP3|CFC|JMML|METCDS|NS1|PTP-1D|PTP2C|SH-PTP2|SH-PTP3|SHP2 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 112418351 End Site(bp): 112509913 Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016] External Links: Ensembl ID: ENSG00000179295 HGNC ID: HGNC:9644 Entrez Gene: 5781

Expression Profile of PTPN11 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-138-5p YES YES YES hsa-miR-143-3p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES YES hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-200b-3p YES NO YES hsa-miR-200c-3p YES NO YES hsa-miR-21-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-218-5p YES NO YES hsa-miR-224-5p YES YES NO hsa-miR-23a-3p YES NO YES hsa-miR-23b-3p YES NO YES hsa-miR-329-3p YES NO NO hsa-miR-362-3p YES NO NO hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-429 YES NO YES hsa-miR-448 YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-499a-5p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-873-5p YES YES NO Display: