ctcRbase

Entry Detail

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General Information

Database ID: SKCM03448 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: EIF2AK4 Full Name: eukaryotic translation initiation factor 2 alpha kinase 4 Category: mRNA Synonyms: GCN2|PVOD2 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 39934146 End Site(bp): 40035591 Gene Summary: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014] External Links: Ensembl ID: ENSG00000128829 HGNC ID: HGNC:19687 Entrez Gene: 440275

Expression Profile of EIF2AK4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-24-3p YES YES NO hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-431-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-543 YES YES YES hsa-miR-93-5p YES YES NO Display: