ctcRbase

Entry Detail

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General Information

Database ID: SKCM03492 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TTL Full Name: tubulin tyrosine ligase Category: mRNA Synonyms: - Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 112482154 End Site(bp): 112541739 Gene Summary: TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008] External Links: Ensembl ID: ENSG00000114999 HGNC ID: HGNC:21586 Entrez Gene: 150465

Expression Profile of TTL Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-101-3p YES YES NO hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-129-2-3p YES NO YES hsa-miR-143-3p YES YES NO hsa-miR-146a-5p YES NO YES hsa-miR-146b-5p YES NO YES hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-186-5p YES YES NO hsa-miR-187-3p YES YES NO hsa-miR-195-5p YES NO YES hsa-miR-196a-5p YES NO YES hsa-miR-196b-5p YES NO YES hsa-miR-197-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-338-3p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-424-5p YES NO YES hsa-miR-497-5p YES NO YES hsa-miR-506-3p YES YES YES hsa-miR-542-3p YES YES NO hsa-miR-599 YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-98-5p YES YES YES Display: