ctcRbase

Entry Detail

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General Information

Database ID: SKCM03523 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PIK3C2A Full Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Category: mRNA Synonyms: CPK|PI3-K-C2(ALPHA)|PI3-K-C2A|PI3K-C2-alpha|PI3K-C2alpha Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 17077730 End Site(bp): 17207983 Gene Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000011405 HGNC ID: HGNC:8971 Entrez Gene: 5286

Expression Profile of PIK3C2A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-1297 YES NO YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-134-5p YES YES NO hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-1-3p YES NO YES hsa-miR-147a YES NO NO hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-195-5p YES NO YES hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-206 YES NO YES hsa-miR-218-5p YES YES YES hsa-miR-219a-5p YES YES YES hsa-miR-223-3p YES YES YES hsa-miR-224-5p YES YES YES hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-26a-5p YES NO YES hsa-miR-26b-5p YES NO YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-31-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-424-5p YES NO YES hsa-miR-448 YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-497-5p YES NO YES hsa-miR-503-5p YES NO YES hsa-miR-506-3p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-613 YES NO YES hsa-miR-653-5p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-9-5p YES YES YES hsa-miR-96-5p YES YES YES Display: