ctcRbase

Entry Detail

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General Information

Database ID: SKCM03535 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DDX50 Full Name: DExD-box helicase 50 Category: mRNA Synonyms: GU2|GUB|RH-II/GuB|mcdrh Chromosome: chr10 Strand: + Coordinate: Start Site(bp): 68901278 End Site(bp): 68946847 Gene Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000107625 HGNC ID: HGNC:17906 Entrez Gene: 79009

Expression Profile of DDX50 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-192-5p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-215-5p YES YES YES hsa-miR-31-5p YES YES NO hsa-miR-342-3p YES YES YES hsa-miR-375 YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-429 YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-875-5p YES YES YES Display: