ctcRbase

Entry Detail

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General Information

Database ID: SKCM03545 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: UPF2 Full Name: UPF2, regulator of nonsense mediated mRNA decay Category: mRNA Synonyms: HUPF2|RENT2|smg-3 Chromosome: chr10 Strand: - Coordinate: Start Site(bp): 11920022 End Site(bp): 12043170 Gene Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000151461 HGNC ID: HGNC:17854 Entrez Gene: 26019

Expression Profile of UPF2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-1297 YES YES NO hsa-miR-137 YES YES YES hsa-miR-138-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-219a-5p YES YES YES hsa-miR-25-3p YES YES YES hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-370-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-485-5p YES YES YES hsa-miR-491-5p YES YES NO hsa-miR-494-3p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: