ctcRbase

Entry Detail

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General Information

Database ID: SKCM03547 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SPAST Full Name: spastin Category: mRNA Synonyms: ADPSP|FSP2|SPG4 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 32063611 End Site(bp): 32157637 Gene Summary: This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The use of alternative translational initiation sites in this gene results in a single transcript variant that can produce isoforms that differ in the length of their N-terminus and which thereby differ in the efficiency of their export from the nucleus to the cytoplasm. In addition, alternative splicing results in multiple transcript variants that encode isoforms that differ in other protein regions as well. One isoform of this gene has been shown to be a microtubule-severing enzyme that regulates microtubule abundance, mobility, and plus-end distribution. Mutations in this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, May 2018] External Links: Ensembl ID: ENSG00000021574 HGNC ID: HGNC:11233 Entrez Gene: 6683

Expression Profile of SPAST Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-132-3p YES YES YES hsa-miR-137 YES YES NO hsa-miR-182-5p YES NO YES hsa-miR-186-5p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-212-3p YES YES YES hsa-miR-218-5p YES NO YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES NO YES hsa-miR-30a-5p YES NO YES hsa-miR-30b-5p YES NO YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES NO YES hsa-miR-30e-5p YES NO YES hsa-miR-335-5p YES YES NO hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-381-3p YES NO YES hsa-miR-383-5p YES YES NO hsa-miR-384 YES YES NO hsa-miR-421 YES YES NO hsa-miR-429 YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-499a-5p YES YES NO hsa-miR-599 YES YES NO hsa-miR-96-5p YES YES YES Display: