ctcRbase

Entry Detail

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General Information

Database ID: SKCM03553 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: OGG1 Full Name: 8-oxoguanine DNA glycosylase Category: mRNA Synonyms: HMMH|HOGG1|MUTM|OGH1 Chromosome: chr3 Strand: + Coordinate: Start Site(bp): 9749944 End Site(bp): 9788219 Gene Summary: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008] External Links: Ensembl ID: ENSG00000114026 HGNC ID: HGNC:8125 Entrez Gene: 4968

Expression Profile of OGG1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-375 YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-98-5p YES YES NO Display: