ctcRbase

Entry Detail

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General Information

Database ID: SKCM03677 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: LRRFIP2 Full Name: LRR binding FLII interacting protein 2 Category: mRNA Synonyms: HUFI-2 Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 37052656 End Site(bp): 37183689 Gene Summary: The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017] External Links: Ensembl ID: ENSG00000093167 HGNC ID: HGNC:6703 Entrez Gene: 9209

Expression Profile of LRRFIP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-1298-5p YES NO YES hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-182-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-324-3p YES NO NO hsa-miR-32-5p YES YES YES hsa-miR-340-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-410-3p YES YES YES hsa-miR-424-5p YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-496 YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-506-3p YES YES NO hsa-miR-599 YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: