ctcRbase

Entry Detail

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General Information

Database ID: SKCM03681 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: UHRF1 Full Name: ubiquitin like with PHD and ring finger domains 1 Category: mRNA Synonyms: ICBP90|Np95|RNF106|TDRD22|hNP95|hUHRF1|huNp95 Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 4903080 End Site(bp): 4962154 Gene Summary: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014] External Links: Ensembl ID: ENSG00000276043 HGNC ID: HGNC:12556 Entrez Gene: 29128

Expression Profile of UHRF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7i-5p YES YES NO hsa-miR-101-3p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-9-5p YES YES NO Display: