ctcRbase

Entry Detail

---



General Information

Database ID: SKCM03722 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GCLM Full Name: glutamate-cysteine ligase modifier subunit Category: mRNA Synonyms: GLCLR Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 93885205 End Site(bp): 93909456 Gene Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] External Links: Ensembl ID: ENSG00000023909 HGNC ID: HGNC:4312 Entrez Gene: 2730

Expression Profile of GCLM Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES NO YES hsa-miR-10b-5p YES NO YES hsa-miR-129-5p YES YES NO hsa-miR-137 YES YES NO hsa-miR-145-5p YES YES YES hsa-miR-183-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-31-5p YES YES YES hsa-miR-323a-3p YES NO YES hsa-miR-32-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-9-5p YES YES YES Display: