ctcRbase

Entry Detail

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General Information

Database ID: SKCM03751 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: NSMCE2 Full Name: NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase Category: mRNA Synonyms: C8orf36|MMS21|NSE2|ZMIZ7 Chromosome: chr8 Strand: + Coordinate: Start Site(bp): 125091679 End Site(bp): 125367120 Gene Summary: This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017] External Links: Ensembl ID: ENSG00000156831 HGNC ID: HGNC:26513 Entrez Gene: 286053

Expression Profile of NSMCE2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-138-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-543 YES YES NO hsa-miR-599 YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO hsa-miR-98-5p YES NO YES Display: