ctcRbase

Entry Detail

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General Information

Database ID: SKCM03771 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ALDH18A1 Full Name: aldehyde dehydrogenase 18 family member A1 Category: mRNA Synonyms: ADCL3|ARCL3A|GSAS|P5CS|PYCS|SPG9|SPG9A|SPG9B Chromosome: chr10 Strand: - Coordinate: Start Site(bp): 95605929 End Site(bp): 95656706 Gene Summary: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000059573 HGNC ID: HGNC:9722 Entrez Gene: 5832

Expression Profile of ALDH18A1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-149-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-300 YES YES NO hsa-miR-370-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-873-5p YES YES NO Display: