ctcRbase

Entry Detail

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General Information

Database ID: SKCM03777 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SCYL2 Full Name: SCY1 like pseudokinase 2 Category: mRNA Synonyms: CVAK104 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 100267140 End Site(bp): 100341724 Gene Summary: The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015] External Links: Ensembl ID: ENSG00000136021 HGNC ID: HGNC:19286 Entrez Gene: 55681

Expression Profile of SCYL2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-205-5p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-875-5p YES YES NO Display: