ctcRbase

Entry Detail

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General Information

Database ID: SKCM03785 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: NFKB1 Full Name: nuclear factor kappa B subunit 1 Category: mRNA Synonyms: CVID12|EBP-1|KBF1|NF-kB1|NF-kappa-B1|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50 Chromosome: chr4 Strand: + Coordinate: Start Site(bp): 102501329 End Site(bp): 102617302 Gene Summary: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016] External Links: Ensembl ID: ENSG00000109320 HGNC ID: HGNC:7794 Entrez Gene: 4790

Expression Profile of NFKB1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-424-5p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-543 YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-9-5p YES YES YES Display: