| ncRNA Symbol: | TOP3A |
| Full Name: | DNA topoisomerase III alpha |
| Category: | mRNA |
| Synonyms: | MGRISCE2|PEOB5|TOP3|ZGRF7 |
| Chromosome: | chr17 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 18271428 | End Site(bp): | 18315007 |
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| Gene Summary: | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] |
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