ctcRbase

Entry Detail

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General Information

Database ID: SKCM03881 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PPM1A Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1A Category: mRNA Synonyms: PP2C-ALPHA|PP2CA|PP2Calpha Chromosome: chr14 Strand: + Coordinate: Start Site(bp): 60245752 End Site(bp): 60299087 Gene Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000100614 HGNC ID: HGNC:9275 Entrez Gene: 5494

Expression Profile of PPM1A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p NO YES YES hsa-miR-106b-5p NO YES YES hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-141-3p NO YES YES hsa-miR-154-5p YES YES NO hsa-miR-15a-5p NO YES YES hsa-miR-15b-5p NO YES YES hsa-miR-16-5p NO YES YES hsa-miR-17-5p NO YES YES hsa-miR-195-5p NO YES YES hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-200a-3p NO YES YES hsa-miR-20a-5p NO YES YES hsa-miR-20b-5p NO YES YES hsa-miR-217 YES YES NO hsa-miR-23a-3p NO YES YES hsa-miR-23b-3p NO YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-338-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-377-3p YES NO YES hsa-miR-410-3p YES YES NO hsa-miR-424-5p NO YES YES hsa-miR-448 YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-487a-3p YES NO YES hsa-miR-497-5p NO YES YES hsa-miR-519d-3p NO YES YES hsa-miR-653-5p YES YES NO hsa-miR-93-5p NO YES YES Display: