ctcRbase

Entry Detail

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General Information

Database ID: SKCM03899 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RAD51 Full Name: RAD51 recombinase Category: mRNA Synonyms: BRCC5|FANCR|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECA Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 40694774 End Site(bp): 40732339 Gene Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] External Links: Ensembl ID: ENSG00000051180 HGNC ID: HGNC:9817 Entrez Gene: 5888

Expression Profile of RAD51 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-134-5p YES NO YES hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-758-3p YES YES YES hsa-miR-9-5p NO YES YES hsa-miR-96-5p NO YES YES Display: