ctcRbase

Entry Detail

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General Information

Database ID: SKCM03974 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: BAG3 Full Name: BCL2 associated athanogene 3 Category: mRNA Synonyms: BAG-3|BIS|CAIR-1|MFM6 Chromosome: chr10 Strand: + Coordinate: Start Site(bp): 119651370 End Site(bp): 119677819 Gene Summary: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000151929 HGNC ID: HGNC:939 Entrez Gene: 9531

Expression Profile of BAG3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-2-3p YES NO YES hsa-miR-143-3p YES YES NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-411-5p YES YES NO Display: