ctcRbase

Entry Detail

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General Information

Database ID: SKCM04052 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TLK2 Full Name: tousled like kinase 2 Category: mRNA Synonyms: HsHPK|MRD57|PKU-ALPHA Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 62458658 End Site(bp): 62615481 Gene Summary: This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] External Links: Ensembl ID: ENSG00000146872 HGNC ID: HGNC:11842 Entrez Gene: 11011

Expression Profile of TLK2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-128-3p YES NO YES hsa-miR-1-3p YES NO YES hsa-miR-143-3p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-186-5p YES NO NO hsa-miR-206 YES NO YES hsa-miR-218-5p YES NO YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-378a-3p YES YES YES hsa-miR-422a YES YES YES hsa-miR-613 YES NO YES Display: