ctcRbase

Entry Detail

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General Information

Database ID: SKCM04060 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: HTRA2 Full Name: HtrA serine peptidase 2 Category: mRNA Synonyms: MGCA8|OMI|PARK13|PRSS25 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 74529377 End Site(bp): 74533348 Gene Summary: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] External Links: Ensembl ID: ENSG00000115317 HGNC ID: HGNC:14348 Entrez Gene: 27429

Expression Profile of HTRA2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-1251-5p YES NO YES hsa-miR-138-5p YES YES YES hsa-miR-145-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-410-3p YES YES YES hsa-miR-519d-3p YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-93-5p YES YES NO Display: