ctcRbase

Entry Detail

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General Information

Database ID: SKCM04104 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SIAH1 Full Name: siah E3 ubiquitin protein ligase 1 Category: mRNA Synonyms: SIAH1A Chromosome: chr16 Strand: - Coordinate: Start Site(bp): 48356364 End Site(bp): 48448402 Gene Summary: This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000196470 HGNC ID: HGNC:10857 Entrez Gene: 6477

Expression Profile of SIAH1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-140-5p YES YES YES hsa-miR-141-3p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-193a-3p YES YES YES hsa-miR-193b-3p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-200a-3p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-205-5p YES YES YES hsa-miR-223-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-299-5p YES NO YES hsa-miR-300 YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-429 YES YES YES hsa-miR-448 YES YES NO hsa-miR-486-5p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-625-5p YES NO NO hsa-miR-653-5p YES YES NO hsa-miR-655-3p YES NO YES Display: