ctcRbase

Entry Detail

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General Information

Database ID: SKCM04116 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: USP8 Full Name: ubiquitin specific peptidase 8 Category: mRNA Synonyms: HumORF8|PITA4|SPG59|UBPY Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 50424380 End Site(bp): 50514419 Gene Summary: This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] External Links: Ensembl ID: ENSG00000138592 HGNC ID: HGNC:12631 Entrez Gene: 9101

Expression Profile of USP8 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-132-3p YES YES YES hsa-miR-155-5p YES YES YES hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-212-3p YES YES YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-328-3p NO YES YES hsa-miR-339-5p YES YES YES hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-382-5p YES YES YES hsa-miR-454-3p YES YES YES hsa-miR-496 YES YES NO hsa-miR-874-3p YES YES YES Display: