ctcRbase

Entry Detail

---



General Information

Database ID: SKCM04118 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PPFIBP1 Full Name: PPFIA binding protein 1 Category: mRNA Synonyms: L2|SGT2|hSGT2|hSgt2p Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 27523431 End Site(bp): 27695564 Gene Summary: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000110841 HGNC ID: HGNC:9249 Entrez Gene: 8496

Expression Profile of PPFIBP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-194-5p YES YES YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-200a-3p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-338-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-410-3p YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-541-3p YES NO NO hsa-miR-543 YES YES NO hsa-miR-654-5p YES NO NO Display: