| ncRNA Symbol: | XPA | | Full Name: | XPA, DNA damage recognition and repair factor | | Category: | mRNA | | Synonyms: | XP1|XPAC | | Chromosome: | chr9 | | Strand: | - | | Coordinate: | | Start Site(bp): | 97674909 | End Site(bp): | 97697357 |
| | Gene Summary: | This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017] | | External Links: | |
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