ctcRbase

Entry Detail

---



General Information

Database ID: SKCM04149 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: AKAP12 Full Name: A-kinase anchoring protein 12 Category: mRNA Synonyms: AKAP250|SSeCKS Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 151239999 End Site(bp): 151358557 Gene Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000131016 HGNC ID: HGNC:370 Entrez Gene: 9590

Expression Profile of AKAP12 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-145-5p YES YES NO hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-183-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES NO YES hsa-miR-214-3p YES NO NO hsa-miR-219a-5p YES NO YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-338-3p YES YES YES hsa-miR-33a-5p NO YES YES hsa-miR-33b-5p NO YES YES hsa-miR-381-3p YES NO YES hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES NO YES hsa-miR-431-5p NO YES YES hsa-miR-455-5p YES YES NO hsa-miR-497-5p YES NO YES hsa-miR-503-5p YES NO NO Display: