ctcRbase

Entry Detail

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General Information

Database ID: SKCM04220 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: EDARADD Full Name: EDAR associated death domain Category: mRNA Synonyms: ECTD11A|ECTD11B|ED3|EDA3 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 236348257 End Site(bp): 236484914 Gene Summary: This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000186197 HGNC ID: HGNC:14341 Entrez Gene: 128178

Expression Profile of EDARADD Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-31-5p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-542-3p YES YES NO Display: