ctcRbase

Entry Detail

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General Information

Database ID: SKCM04231 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GSR Full Name: glutathione-disulfide reductase Category: mRNA Synonyms: GR|HEL-75|HEL-S-122m Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 30678061 End Site(bp): 30727926 Gene Summary: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010] External Links: Ensembl ID: ENSG00000104687 HGNC ID: HGNC:4623 Entrez Gene: 2936

Expression Profile of GSR Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES YES hsa-miR-1298-5p YES NO YES hsa-miR-136-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-485-5p YES YES NO Display: