ctcRbase

Entry Detail

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General Information

Database ID: SKCM04362 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ASXL1 Full Name: ASXL transcriptional regulator 1 Category: mRNA Synonyms: BOPS|MDS Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 32358344 End Site(bp): 32439319 Gene Summary: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] External Links: Ensembl ID: ENSG00000171456 HGNC ID: HGNC:18318 Entrez Gene: 171023

Expression Profile of ASXL1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-128-3p NO YES YES hsa-miR-141-3p YES YES YES hsa-miR-149-5p NO YES YES hsa-miR-153-3p YES YES YES hsa-miR-183-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-200a-3p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-27a-3p NO YES YES hsa-miR-27b-3p NO YES YES hsa-miR-300 YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-326 YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-429 YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-496 YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-9-5p YES YES YES Display: