ctcRbase

Entry Detail

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General Information

Database ID: SKCM04418 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SF1 Full Name: splicing factor 1 Category: mRNA Synonyms: BBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 64764606 End Site(bp): 64778786 Gene Summary: This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] External Links: Ensembl ID: ENSG00000168066 HGNC ID: HGNC:12950 Entrez Gene: 7536

Expression Profile of SF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-143-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-149-5p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-184 YES YES YES hsa-miR-185-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-328-3p YES NO YES hsa-miR-346 YES YES YES hsa-miR-369-3p YES NO YES hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-410-3p YES YES YES hsa-miR-421 YES YES NO hsa-miR-485-5p YES YES YES hsa-miR-490-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-505-3p YES YES YES hsa-miR-543 YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-665 YES NO YES Display: