| ncRNA Symbol: | COQ3 | | Full Name: | coenzyme Q3, methyltransferase | | Category: | mRNA | | Synonyms: | DHHBMT|DHHBMTASE|UG0215E05|bA9819.1 | | Chromosome: | chr6 | | Strand: | - | | Coordinate: | | Start Site(bp): | 99369400 | End Site(bp): | 99394204 |
| | Gene Summary: | Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008] | | External Links: | |
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