| ncRNA Symbol: | CFHR1 |
| Full Name: | complement factor H related 1 |
| Category: | mRNA |
| Synonyms: | CFHL|CFHL1|CFHL1P|CFHR1P|FHR1|H36-1|H36-2|HFL1|HFL2 |
| Chromosome: | chr1 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 196819757 | End Site(bp): | 196832189 |
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| Gene Summary: | This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009] |
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