ctcRbase

Entry Detail

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General Information

Database ID: SKCM04584 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TDG Full Name: thymine DNA glycosylase Category: mRNA Synonyms: hTDG Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 103965804 End Site(bp): 103988874 Gene Summary: The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000139372 HGNC ID: HGNC:11700 Entrez Gene: 6996

Expression Profile of TDG Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-124-3p YES YES YES hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-1297 YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-144-3p YES NO YES hsa-miR-150-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-192-5p YES YES YES hsa-miR-206 YES YES NO hsa-miR-215-5p YES YES YES hsa-miR-216b-5p YES YES NO hsa-miR-217 YES NO YES hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-338-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-613 YES YES NO Display: