ctcRbase

Entry Detail

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General Information

Database ID: SKCM04621 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ACO1 Full Name: aconitase 1 Category: mRNA Synonyms: ACONS|HEL60|IREB1|IREBP|IREBP1|IRP1 Chromosome: chr9 Strand: + Coordinate: Start Site(bp): 32384603 End Site(bp): 32454769 Gene Summary: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014] External Links: Ensembl ID: ENSG00000122729 HGNC ID: HGNC:117 Entrez Gene: 48

Expression Profile of ACO1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES NO hsa-miR-141-3p YES YES YES hsa-miR-150-5p YES NO YES hsa-miR-185-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-200a-3p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-299-3p YES YES NO hsa-miR-383-5p YES NO YES hsa-miR-495-3p YES YES YES hsa-miR-599 YES YES NO hsa-miR-96-5p YES YES NO Display: