ctcRbase

Entry Detail

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General Information

Database ID: SKCM04660 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PARN Full Name: poly(A)-specific ribonuclease Category: mRNA Synonyms: DAN|DKCB6|PFBMFT4 Chromosome: chr16 Strand: - Coordinate: Start Site(bp): 14435701 End Site(bp): 14632728 Gene Summary: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] External Links: Ensembl ID: ENSG00000140694 HGNC ID: HGNC:8609 Entrez Gene: 5073

Expression Profile of PARN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-206 YES YES NO hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-329-3p YES NO NO hsa-miR-335-5p YES YES NO hsa-miR-362-3p YES NO NO hsa-miR-377-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-613 YES YES NO Display: