ctcRbase

Entry Detail

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General Information

Database ID: SKCM04683 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: KRIT1 Full Name: KRIT1, ankyrin repeat containing Category: mRNA Synonyms: CAM|CCM1 Chromosome: chr7 Strand: - Coordinate: Start Site(bp): 92198969 End Site(bp): 92246166 Gene Summary: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009] External Links: Ensembl ID: ENSG00000001631 HGNC ID: HGNC:1573 Entrez Gene: 889

Expression Profile of KRIT1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-147a YES NO NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-329-3p YES YES YES hsa-miR-335-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-361-5p YES YES NO hsa-miR-362-3p YES YES YES hsa-miR-365a-3p YES YES NO hsa-miR-371a-5p YES YES YES hsa-miR-410-3p YES YES YES hsa-miR-421 YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-590-5p YES YES YES hsa-miR-599 YES YES NO hsa-miR-653-5p YES YES NO Display: