ctcRbase

Entry Detail

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General Information

Database ID: SKCM04693 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RYK Full Name: receptor-like tyrosine kinase Category: mRNA Synonyms: D3S3195|JTK5|JTK5A|RYK1 Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 134065303 End Site(bp): 134250744 Gene Summary: The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012] External Links: Ensembl ID: ENSG00000163785 HGNC ID: HGNC:10481 Entrez Gene: 6259

Expression Profile of RYK Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-1297 YES YES YES hsa-miR-137 YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-219a-2-3p YES NO YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-324-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-452-5p YES NO YES hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES YES hsa-miR-519d-3p YES YES NO hsa-miR-7-5p YES YES YES hsa-miR-93-5p YES YES NO hsa-miR-96-5p YES YES YES Display: