ctcRbase

Entry Detail

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General Information

Database ID: SKCM04699 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SMAD2 Full Name: SMAD family member 2 Category: mRNA Synonyms: JV18|JV18-1|MADH2|MADR2|hMAD-2|hSMAD2 Chromosome: chr18 Strand: - Coordinate: Start Site(bp): 47808957 End Site(bp): 47931146 Gene Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] External Links: Ensembl ID: ENSG00000175387 HGNC ID: HGNC:6768 Entrez Gene: 4087

Expression Profile of SMAD2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-128-3p YES NO YES hsa-miR-132-3p YES NO YES hsa-miR-135a-5p YES NO YES hsa-miR-135b-5p YES NO YES hsa-miR-140-5p YES NO YES hsa-miR-142-5p YES NO YES hsa-miR-148a-3p YES NO YES hsa-miR-148b-3p YES NO YES hsa-miR-152-3p YES NO YES hsa-miR-155-5p YES NO YES hsa-miR-188-5p YES NO YES hsa-miR-18a-5p YES NO YES hsa-miR-18b-5p YES NO YES hsa-miR-200b-3p YES NO YES hsa-miR-200c-3p YES NO YES hsa-miR-212-3p YES NO YES hsa-miR-219a-5p YES NO YES hsa-miR-27a-3p YES NO YES hsa-miR-27b-3p YES NO YES hsa-miR-302a-3p YES NO YES hsa-miR-302b-3p YES NO YES hsa-miR-302c-3p YES NO YES hsa-miR-302d-3p YES NO YES hsa-miR-302e YES NO YES hsa-miR-30a-5p YES NO YES hsa-miR-30b-5p YES NO YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES NO YES hsa-miR-30e-5p YES NO YES hsa-miR-323a-3p YES NO YES hsa-miR-329-3p YES NO YES hsa-miR-340-5p YES NO YES hsa-miR-362-3p YES NO YES hsa-miR-372-3p YES NO YES hsa-miR-373-3p YES NO YES hsa-miR-410-3p YES NO YES hsa-miR-425-5p YES NO YES hsa-miR-429 YES NO YES hsa-miR-433-3p YES NO YES hsa-miR-452-5p YES NO YES hsa-miR-455-3p YES NO YES hsa-miR-486-5p YES YES YES hsa-miR-520a-3p YES NO YES hsa-miR-520b YES NO YES hsa-miR-520c-3p YES NO YES hsa-miR-520d-3p YES NO YES hsa-miR-520e YES NO YES hsa-miR-532-5p YES NO YES hsa-miR-876-5p YES NO YES Display: