ctcRbase

Entry Detail

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General Information

Database ID: SKCM04704 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TP53BP1 Full Name: tumor protein p53 binding protein 1 Category: mRNA Synonyms: 53BP1|TDRD30|p202|p53BP1 Chromosome: chr15 Strand: - Coordinate: Start Site(bp): 43403061 End Site(bp): 43510728 Gene Summary: This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000067369 HGNC ID: HGNC:11999 Entrez Gene: 7158

Expression Profile of TP53BP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-145-5p YES YES NO hsa-miR-300 YES YES YES hsa-miR-329-3p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-421 YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-543 YES YES NO Display: