ctcRbase

Entry Detail

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General Information

Database ID: SKCM04715 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DPH1 Full Name: diphthamide biosynthesis 1 Category: mRNA Synonyms: DEDSSH|DPH2L|DPH2L1|OVCA1 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 2030110 End Site(bp): 2043430 Gene Summary: The protein encoded by this gene is an enzyme involved in the biosynthesis of diphthamide, a modified histidine found only in elongation factor-2 (EEF2). Diphthamide residues in EEF2 are targeted for ADP-ribosylation by diphtheria toxin and Pseudomonas exotoxin A. Defects in this gene have been associated with both ovarian cancer and autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies. [provided by RefSeq, Oct 2016] External Links: Ensembl ID: ENSG00000108963 HGNC ID: HGNC:3003 Entrez Gene: 1801

Expression Profile of DPH1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-1-3p YES NO YES hsa-miR-206 YES NO YES hsa-miR-28-5p YES YES NO hsa-miR-485-5p YES NO YES hsa-miR-613 YES NO YES hsa-miR-708-5p YES YES NO hsa-miR-98-5p YES YES YES Display: