ctcRbase

Entry Detail

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General Information

Database ID: SKCM04729 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: UTRN Full Name: utrophin Category: mRNA Synonyms: DMDL|DRP|DRP1 Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 144285701 End Site(bp): 144853034 Gene Summary: This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000152818 HGNC ID: HGNC:12635 Entrez Gene: 7402

Expression Profile of UTRN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-103a-3p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-107 YES YES NO hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-140-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-142-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-206 YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-613 YES YES YES hsa-miR-7-5p YES YES NO hsa-miR-875-5p YES YES NO hsa-miR-93-5p YES YES NO hsa-miR-9-5p YES YES NO hsa-miR-98-5p YES YES YES Display: